Yüksek Lisans Tez Başlığı: 
Studies on novel omega-aminotransferases from Klebsiella pneumoniae (Danışman: Prof. Dr. Jennifer Littlechild)

Doktora Tez Başlığı:
Glyceraldehyde-3-phosphate Dehydrogenase and Fructose-1, 6-bisphosphatase of the Enteric Pathogens C. jejuni and H. pylori (Danışman: Prof. Dr. Peter Moody)

Tezden Çıkmış Yayınlar

1. Özbolat, S. N., & Ayna, A. (2021). Chrysin suppresses HT-29 cell death induced by diclofenac through apoptosis and oxidative damage. Nutrition and Cancer, 73(8), 1419-1428.

2. Ayna, A., & Varan, S. N. (2023). Investigation of the Protective Effects of Chrysin Against Paclitaxel-Induced Oxidative Stress and Apoptosis in Human Neuronal SH-SY5Y Cells. Türk Doğa ve Fen Dergisi, 12(4), 107-113.

3. Ayna, A., & Nerway, F. (2024). Evaluation of Sun Protection Factor of Northern Iraqi Propolis. Türk Doğa ve Fen Dergisi, 13(3), 57-61.

AYNA ADNAN, VARAN SEMA NUR (2023). Investigation of the Protective Effects of Chrysin Against Paclitaxel-Induced Oxidative Stress and Apoptosis in Human Neuronal SH-SY5Y Cells. Bingol Universitesi, 12(4), 107-113., Doi: 10.46810/tdfd.1375041 

SANCAK SEDANUR, YAZGAN İDRİS, UĞURLU BAYARSLAN ASLI, AYNA ADNAN, EVECEN SENANUR, TAŞDELEN ZEHRA, GÜMÜŞ ABDURRAHMAN,SÖNMEZ HAMİDE AYÇİN, DEMİR MEHMET ALİ, DEMİR SOSİN, BAKAR FATMA, DİLEK TEPE HAFİZE, KASEMETS KAJA, OTSUS MAARJA, ÇETER TALİP (2023). Surface chemistry dependent toxicity of inorganic nanostructure glycoconjugates on bacterial cells and cancer cell lines. Journal of Drug Delivery Science and Technology, 79, 104054

ATASOY SELÇUK, KURUL YASIN, AKTAŞ SITKI, SARCAN FAHRETTİN, KURT MUSTAFA ŞÜKRÜ, AYNA ADNAN, DARENDELİOĞLU EKREM, EROL AYŞE (2023). Selective Antimicrobial Properties of W-Ge Nanocomposite Thin Films. Physics and Astronomy Reports, 1(1), 38-43., Doi: 10.26650/PAR.2023.00005

KIZIL HAMİT EMRE, GÜR CİHAN, AYNA ADNAN, DARENDELİOĞLU EKREM, KÜÇÜKLER SEFA, SAĞ SEVDA (2023). Contribution of Oxidative Stress, Apoptosis, Endoplasmic Reticulum Stress and Autophagy Pathways to the Ameliorative Effects of Hesperidin in NaF‐Induced Testicular Toxicity. Chemistry & Biodiversity, 20, Doi: 10.1002/cbdv.202200982 

KIZIL HAMİT EMRE, ÇAĞLAYAN CÜNEYT, DARENDELİOĞLU EKREM, AYNA ADNAN, GÜR CİHAN, KANDEMİR FATİH MEHMET, KÜÇÜKLER SEFA (2023). Morin ameliorates methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways. Molecular Biology Reports, 50(4), 3479-3488., Doi: 10.1007/s11033-023-08286-8 

VARIŞLI BEHÇET, ÇAĞLAYAN CÜNEYT, KANDEMİR FATİH MEHMET, GÜR CİHAN, AYNA ADNAN, GENÇ AYDIN, TAYSI SEYİTHAN (2023). Chrysin mitigates diclofenac-induced hepatotoxicity by modulating oxidative stress, apoptosis, autophagy and endoplasmic reticulum stress in rats. Molecular Biology Reports, 50(1), 433-442., Doi: 10.1007/s11033-022-07928-7 

AYNA ADNAN, DARENDELİOĞLU EKREM (2022). Evaluation of the Biological Activities of Royal Jelly on Prostate and Breast Cancer Cells. Türk Doğa ve Fen Dergisi, 11(3), 166-170., Doi: 10.46810/tdfd.1149604

ÇAĞLAYAN CÜNEYT, KANDEMİR FATİH MEHMET, AYNA ADNAN, GÜR CİHAN, KÜÇÜKLER SEFA, DARENDELİOĞLU EKREM (2022). Neuroprotective effects of 18β-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1/STAT1 signaling pathway. Metabolic Brain Disease, 37, 1931-1940., Doi: 10.1007/s11011-022-01027-z )

VARIŞLI BEHÇET, DARENDELİOĞLU EKREM, ÇAĞLAYAN CÜNEYT, KANDEMİR FATİH MEHMET, AYNA ADNAN, GENÇ AYDIN, KANDEMİR ÖZGE (2022). Hesperidin Attenuates Oxidative Stress, Inflammation, Apoptosis, and Cardiac Dysfunction in Sodium Fluoride‐Induced Cardiotoxicity in Rats. Cardiovascular Toxicology, 22, 727-735., Doi: 10.1007/s12012-022-09751-9 

ÇALIŞKAN ERAY, AYNA ADNAN, TUNÇ ABDULLAH, ÖZBOLAT SEDANUR, BENGÜ AYDIN ŞÜKRÜ, AYKUTOĞLU GÜRKAN, ÇİFTCİ MEHMET, DARENDELİOĞLU EKREM (2021). Antioxidant Activities of Bingöl Royal Jelly on SH-SY5Y Cells. International Journal of Nature and Life Sciences, Doi: 10.47947/1008223 

AYNA ADNAN, TUNÇ ABDULLAH, ÖZBOLAT SEDA NUR, BENGÜ AYDIN ŞÜKRÜ, AYKUTOĞLU GÜRKAN, CANLI DENİZ, POLAT RIDVAN, ÇİFTCİ MEHMET, DARENDELİOĞLU EKREM (2021). Anticancer, and antioxidant activities of royal jelly on HT-29 colon cancer cells and melissopalynological analysis. TURKISH JOURNAL OF BOTANY, 45, 809-819., Doi: 10.3906/bot-2109-8 

AYNA ADNAN, MOODY PETER (2021). Crystal structures of a dual coenzyme specific glyceraldehyde-3-phosphate dehydrogenase from the enteric pathogen Campylobacter jejuni. Journal of Molecular Structure, 1242, 1-12., Doi: 10.1016/j.molstruc.2021.130820 

ÇAĞLAYAN CÜNEYT, KANDEMİR FATİH, DARENDELİOĞLU EKREM, KÜÇÜKLER SEFA, AYNA ADNAN (2021). Hesperidin protects liver and kidney against sodium fluoride-induced toxicity through anti-apoptotic and anti-autophagic mechanisms. Life Sciences, 281, Doi: 10.1016/j.lfs.2021.119730 

ÖZBOLAT SEDA NUR, AYNA ADNAN (2021). Chrysin Suppresses HT-29 Cell Death Induced by Diclofenac through Apoptosis and Oxidative Damage. Nutrition and Cancer, 73(8), 1419-1428., Doi: 10.1080/01635581.2020.1801775 

ZENGİN GÖKHAN, FAWZI MAHOMOODALLY MOHAMAD, AKTÜMSEK ABDURRAHMAN, JEKŐ JÓZSEF, CZİÁKY ZOLTÁN, RODRİGUES MARİA JOÃO, CUSTODİO LUİSA, POLAT RIDVAN, ÇAKILCIOĞLU UĞUR, AYNA ADNAN, GALLO MONİCA, MONTESANO DOMENİCO, PİCOT-ALLAİN CARENE (2021). Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey. Plants-Basel, 10(6), 1-15., Doi: 10.3390/plants10061176 

KÜÇÜKLER SEFA,BENZER FULYA,YILDIRIM SERKAN,GÜR CİHAN,KANDEMİR FATİH MEHMET,BENGÜ AYDIN ŞÜKRÜ,AYNA ADNAN,ÇAĞLAYAN CÜNEYT,DÖRTBUDAK MUHAMMET BAHAEDDİN (2021). Protective Effects of Chrysin Against Oxidative Stress and Inflammation Induced by Lead Acetate in Rat Kidneys: a Biochemical and Histopathological Approach. Biological Trace Element Research, 199(4), 1501-1514., Doi: 10.1007/s12011-020-02268-8 

AYNA ADNAN,TEMEL YUSUF,ÇİFTCİ MEHMET,KHOSNAW LUQMAN (2021). Antibiotics as Inhibitor of Glutathione S-transferase: Biological Evaluation and Molecular Structure Studies. Current Drug Metabolism, 22(4), 308-314., Doi: 10.2174/1389200222666210118102700 

AYNA ADNAN (2021). Caffeic acid prevents hydrogen peroxide-induced oxidative damage in SH-SY5Y cell line through mitigation of oxidative stress and apoptosis. Bratislava Medical Journal, 122(2), 120-124., Doi: 10.4149/BLL_2021_018 

AYNA ADNAN, ÖZBOLAT SEDA NUR, DARENDELİOĞLU EKREM (2020). Quercetin, chrysin, caffeic acid and ferulic acid ameliorate cyclophosphamide-induced toxicities in SH-SY5Y cells. Molecular Biology Reports, 47, 8535-8543., Doi: 10.1007/s11033-020-05896-4 

KÜÇÜKLER SEFA,DARENDELİOĞLU EKREM,ÇAĞLAYAN CÜNEYT,AYNA ADNAN,YILDIRIM SERKAN,KANDEMİR FATİH MEHMET (2020). Zingerone attenuates vancomycin-induced hepatotoxicity in rats through regulation of oxidative stress, inflammation and apoptosis. Life Sciences, 259, 118382, Doi: 10.1016/j.lfs.2020.118382 

AYNA ADNAN, MOODY PETER (2020). Activity of fructose-1,6-bisphosphatase from Campylobacter jejuni. Biochemistry and Cell Biology, 98(4), 518-524., Doi: 10.1139/bcb-2020-0021 

AYKUTOĞLU GÜRKAN, TARTIK MUSA, DARENDELİOĞLU EKREM, AYNA ADNAN, BAYDAŞ GİYASETTİN (2020). Melatonin and vitamin E alleviate homocysteine-induced oxidative injury and apoptosis in endothelial cells. MOLECULAR BIOLOGY REPORTS, 47(7), 5285-5293., Doi: 10.1007/s11033-020-05607-z 

BAYINDIR SİNAN, TEMEL YUSUF, AYNA ADNAN, ÇİFTCİ MEHMET (2018). The synthesis of N -benzoylindoles as inhibitors of rat erythrocyte glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase. Journal of Biochemical and Molecular Toxicology, 32(9), 22193, Doi: 10.1002/jbt.22193 

TEMEL YUSUF, AYNA ADNAN, HAMDİ SHAFEEQ İBRAHİM, ÇİFTCİ MEHMET (2018). In vitro effects of some antibiotics on glucose-6-phosphate dehydrogenase from rat (Rattus norvegicus) erythrocyte. Drug and Chemical Toxicology, 43(2), 219-223., Doi: 10.1080/01480545.2018.1481083 

BAYINDIR SİNAN,AYNA ADNAN,TEMEL YUSUF,ÇİFTCİ MEHMET (2018). The synthesis of new oxindoles as analogs of natural product 3,3\u2032-bis(indolyl)oxindole and in vitro evaluation of the enzyme activity of G6PD and 6PGD. TURKISH JOURNAL OF CHEMISTRY, 42(2), 332-345., Doi: 10.3906/kim-1706-51 

AYNA ADNAN (2017). Structural Studies of PhosphoenolpyruvateCarboxykinase in Campylobacter jejuni. Imperial Journal of Interdisciplinary research, 3(3), 1062-1066

AYNA ADNAN (2017). Purification and Characterisation ofPhosphoenolpyruvate Carboxykinase in C. jejuni. Imperial Journal of Interdisciplinary Research, 3(3), 1363-1366 

1. AYNA ADNAN (2020). APOPTOTIC EFFECTS OF BETA-CAROTENE, ALPHA-TOCOPHEROL AND ASCORBIC ACID ON PC-3 PROSTATE CANCER CELLS. Hacettepe Journal of Biology and Chemistry, 48(3), 1. 211-218., Doi: 10.15671/hjbc.519212 

2. BENGÜ AYDIN ŞÜKRÜ, AYNA ADNAN, ÖZBOLAT SEDA NUR, TUNÇ ABDULLAH, AYKUTOĞLU GÜRKAN, ÇİFTCİ MEHMET, DARENDELİOĞLU EKREM (2020). Content and Antimicrobial Activities of Bingol Royal Jelly. Türk Tarım ve Doğa Bilimleri Dergisi(2), 480-489., Doi: 10.30910/turkjans.725977 

3. AYNA ADNAN,AKYILMAZ EROL (2018). Development of a Biosensor Based on Myrtle (Myrtus communis L.) Tissue Homogenate for Voltammetric Determination of Epinephrine. Hacettepe Journal of Biology and Chemistry, 46(3), 321-328., Doi: 10.15671/HJBC.2018.240 (Kontrol No: 4661364)

1. Adnan Ayna and Peter Moody “Understanding the metabolism of enteric pathogen Campylobacter jejuni”,  Protein Science 23, 172172, 27-30 July 2014, San Diego, USA. (Poster presentation)
2. Adnan Ayna and Peter Moody “Crystallographic and kinetic studies on glyceraldehyde-3-phosphate dehydrogenase from Campylobacter jejuni”, 22nd CCP4 Northern Protein Structure Workshop, 26-28 August 2015, Carlisle, England. (Oral presentation)
3. Adnan Ayna, Sinan Bayindir and Yusuf Temel "Synthesis of 3,3'-bisindoles and investigation of the effect on rat erythrocyte 6PGD", International Engineerimg, Science and Education Conference, December 2016, Diyarbakir, Turkey. (Full paper)
4. Adnan Ayna, Sinan Bayindir and Yusuf Temel. Determination of The Effect of 3,3′-bisindole Derivatives On Rat Erythrocyte 6PGD: An In Vitro and In Silico Study. International Conference on Advances and Innovations in Engineering. 10-12 May, 2017, Elazig, Turkey. (PDF). 
5. Adnan Ayna, Sinan Bayindir and Yusuf Temel. New Heterocyclic Compounds as Inhibitors of Rat Erythrocytes G6PD and 6PGD and Docking Studies. International Conference on Advances and Innovations in Engineering. 10-12 May, 2017, Elazig, Turkey. (PDF). 
6. Sinan Bayindir, Adnan Ayna and Yusuf Temel. Design and Synthesis of Indole Derivatives for the Inhibition of G6PD and Detailed in Silico Studies. International Conference on Advances and Innovations in Engineering. 10-12 May, 2017, Elazig, Turkey. (PDF).   
7. Sinan Bayindir, Adnan Ayna and Yusuf Temel. Investigation the effects of hetero aromatic compounds on rat erythrocyte 6PGD and in silico molecular docking experiments. International Conference on Advances and Innovations in Engineering. 10-12 May, 2017, Elazig, Turkey. (PDF). 
8. Yusuf Temel, Sinan Bayindir and Adnan Ayna. New amide derivatives as inhibitors of glucose 6phosphate dehydrogenase and docking studies. International Conference on Advances and Innovations in Engineering. 10-12 May, 2017, Elazig, Turkey. (PDF).  
9. Yusuf Temel, Adnan Ayna and Mehmet Ciftci. Some antibiotics as inhibitors and activators of rat erythrocyte 6PGD and G6PD. International Conference on Advances and Innovations in Engineering. 10-12 May, 2017, Elazig, Turkey. (PDF). 
10. Adnan Ayna, Luqman Khosnaw, Yusuf Temel, Sinan Bayindir and Mehmet Çiftci. Investigating the effect of benzamides on the activity of rat erythrocyte GST, 8th International Advanced Technologies Symposium. 19-22 October 2017, Elazig Turkey (PDF)
11. Adnan Ayna and Peter Moody. Cloning, Purification and Characterization of Fructose-1,6-bisphospahatase of Helicobacter Pylori. 8th International Advanced Technologies Symposium. 19-22 October 2017, Elazig Turkey (PDF).
12. Ercan Asi, Adnan Ayna and Hasan Yesilkaya. Investigating the factors affecting bacteriocin production in Streptococcus pneumoniae. 1st International Health Science and Life Congress (IHSLC). 02-05 May 2018, Burdur Turkey (Oral presentation)
13. Ercan Asi and Adnan Ayna. The impact of kidney disease on the patient, hıs/her family and the healthcare providers. 1st International Health Science and Life Congress (IHSLC). 02-05 May 2018, Burdur Turkey (Poster presentation)
14. AYNA ADNAN, ÖZBOLAT SEDA NUR (2020). Protective Effects of Ferulic Acid against Diclofenac Induced Toxicities in SHSY5Y Cells. 3rd International Conference on Physical Chemistry and Functional Materials (Özet Bildiri/Sözlü Sunum)
15. AYNA ADNAN (2020). AN INVESTIGATION OF THE EFFECT OF CAFFEIC ACID AND QUERCETIN ON DICLORON INDUCED TOXICITY IN CACO-2 CELLS. 6th INTERNATIONAL CONFERENCE ON ENGINEERING NATURAL SCIENCES (Özet Bildiri/Sözlü Sunum)
16. TEMEL YUSUF,BENGÜ AYDIN ŞÜKRÜ,ESİM NEVZAT,AVCİ VEDAT,POLAT RIDVAN,CANLI DENİZ,ERDOĞAN İBRAHİM YASİN,SOLMAZ RAMAZAN,ÇİFTCİ MEHMET,AYNA ADNAN (2019). BİNGÖL BALININ ENZİMATİK ANALİZİ VE BAZI BİYOKİMYASALPARAMETRELERİNİN BELİRLENMESİ. ULUSLARARASI ARICILIK ARAŞTIRMALARI VE SÜRDÜRÜLEBİLİR KIRSAL KALKINMA STRATEJİLERİ KONGRESİ (Özet Bildiri/Sözlü Sunum)(Yayın No:5736269)
17. DARENDELİOĞLU EKREM, AYNA ADNAN, ÖZBOLAT SEDA NUR, ÇİFTCİ MEHMET, AYKUTOĞLU GÜRKAN, BENGÜ AYDIN ŞÜKRÜ, TUNÇ ABDULLAH (2019). CONTENT AND APOPTOTIC EFFECT OF BINGOL ROYAL JELLY ON COLON CANCER CELLS. ULUSLARARASI ARICILIK ARAŞTIMALARI VE SÜRDÜRÜLEBİLİR KIRSAL KALKINMA STRATEJİLERİ KONGRESİ (Özet Bildiri/Sözlü Sunum)
18. AYNA ADNAN, ÖZBOLAT SEDA NUR, DARENDELİOĞLU EKREM (2019). SECONDER METABOLITE ANALYSIS OF Lactobacillus pentosus vs. Pediococcus pentosaceus. EURASIA 3rd INTERNATIONAL CONGRESS OF APPLIED SCIENCES (Özet Bildiri/Sözlü Sunum)
19. TEMEL YUSUF, AYNA ADNAN, BENGÜ AYDIN ŞÜKRÜ, ESİM NEVZAT, AVCİ VEDAT, POLAT RIDVAN, CANLI DENİZ, BAYRAM NESRİN ECEM, ERDOĞAN İBRAHİM YASİN, SOLMAZ RAMAZAN, ÇİFTCİ MEHMET (2019). BIOCHEMICAL PARAMETERS OF BINGÖL/TURKEY HONEY. 7th. International Conference on mathematics, Engineering, Natural Medical Sciences, 1(1), 42-43. (Özet Bildiri/Sözlü Sunum)
20. AYNA ADNAN, BENGÜ AYDIN ŞÜKRÜ, AYKUTOĞLU GÜRKAN, ÇİFTCİ MEHMET, DARENDELİOĞLU EKREM, ÖZBOLAT SEDA NUR (2019). ANTICANCER and ANTIOXIDANT ACTIVITY OF BİNGOL ROYAL JELLY. 7th INTERNATIONAL MATHEMATICS-ENGINEERING-SCIENCE AND HEALTH SCIENCES CONGRESS (Özet Bildiri/Sözlü Sunum)
21. AYNA ADNAN (2019). INHIBITION STUDIES OF CAMPYLOBACTER JEJUNI GAPDH. 7th. INTERNATIONAL CONFERENCEON MATHEMATICS, ENGINEERING,NATURAL MEDICAL SCIENCES (Özet Bildiri/Sözlü Sunum)(Yayın No:6384546)
22. DARENDELİOĞLU EKREM, BENGÜ AYDIN ŞÜKRÜ, AYNA ADNAN, AYKUTOĞLU GÜRKAN, ÇİFTCİ MEHMET, ÖZBOLAT SEDA NUR (2019). MINERAL CONTENT AND ANTIMICROBIAL ACTIVITY OF BINGOL ROYAL JELLY. 7th INTERNATIONAL MATHEMATICS-ENGINEERING-SCIENCE AND HEALTH SCIENCES CONGRESS (Özet Bildiri/Sözlü Sunum)
23. AYKUTOĞLU GÜRKAN,DARENDELİOĞLU EKREM,AYNA ADNAN,ÇİFTCİ MEHMET (2018). The Effects of Beta Carotene on Colon Cancer (HT-29) Cells. International Conference on Pyhsical Chemistry and Functional Materials (Özet Bildiri/Poster)(Yayın No:4882428) 10. AYKUTOĞLU GÜRKAN,DARENDELİOĞLU EKREM,AYNA ADNAN,ÇİFTCİ MEHMET (2018). The Effects of Ascorbic Acid on Colon Cancer (HT-29) Cells. International Conference on Pyhsical Chemistry and Functional Materials (Özet Bildiri/Poster)
24. AYKUTOĞLU GÜRKAN,DARENDELİOĞLU EKREM,AYNA ADNAN,ÇİFTCİ MEHMET (2018). The Effects of Alpha-Tocopherol on Colon Cancer (HT-29) Cells. International Conference on Physical Chemistry and Functional Materials (Özet Bildiri/Poster)(Yayın No:4882433) 

1. Bingöl Merkez ve ilçelerinde bal üretimi, Bingöl balında bulunan çeşitli enzimlerin analizi, bazı biyokimyasal parametrelerin ve melissapalinolojik özelliklerin belirlenmesi. PİKOM-Arı.2018.004 (Araştırmacı-Devam ediyor)

2. Bingöl Arı sütünün biyolojik aktivitelerinin belirlenmesi. PİKOM-Arı.2018.001 (Araştırmacı)

3. Dikofenak ile indüklenmiş Ht-29 hücre hattı üzerinde krisinin moleküler ve biyokimyasal etkileri (Yürütücü)

4. Lactobacillus plantarum ve Lactobacillus pentosus Türlerinden Elde Edilen Bazı Kısa Zincirli Yağ Asitlerinin Anti-Mikrobiyal ve Kemoterapotik İlaçla  İndüklenmiş İnsan Nöron Hücrelerinde (SH-SY5Y) Koruyucu Etkilerinin Araştırılması (Araştırmacı)

Symposiums  

•  Midlands Biophysics network – 6th annual meeting at Birmingham University Biosciences, Birmingham, England, 18 December 2013. 
•  5th Annual Midlands Biophysics Network Symposium, at the School of Life and Health Sciences, Aston University, Birmingham, England, 18 April 2012. 
•  CCP4 Study Weekend. “Protein-Ligand Complexes: Understanding Biological Chemistry”, Nottingham, England, 8-10 January 2016. 
• CCP4 Study Weekend. "Advances in Experimental Phasing", Nottingham, England, 7-9 January 2015.